TRASTUZUMAB MOA SECRETS

The phosphorylated HER3 delivers docking web pages for p85 subunit of PI3K. The absolutely activated PI3K complex is created by binding of p110 subunit of PI3K to p85 which is able to deliver PIP3 by using phosphorylating the PIP2. AKT binds to PIP3 and is particularly phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at both threonine and